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Massage-like stroking of the abdomen lowers blood pressure in anesthetized rats: influence of oxytocin

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      Abstract

      The aim of this study was to determine how massage-like stroking of the abdomen in rats influences arterial blood pressure. The participation of oxytocinergic mechanisms in this effect was also investigated. The ventral and/or lateral sides of the abdomen were stroked at a speed of 20 cm/s with a frequency of 0.017–0.67 Hz in pentobarbital anesthetized, artificially ventilated rats. Arterial blood pressure was recorded with a pressure transducer via a catheter in the carotid artery. Stroking of the ventral, or both ventral and lateral sides of the abdomen for 1 min with a frequency of 0.67 Hz caused a marked decrease in arterial blood pressure (approx. 50 mmHg). After cessation of the stimulation blood pressure returned to the control level within 1 min. The maximum decrease in blood pressure was achieved at frequencies of 0.083 Hz or more. Stroking only the lateral sides of the abdomen elicited a significantly smaller decrease in blood pressure (approx. 30 mmHg decrease) than stroking the ventral side. The decrease in blood pressure caused by stroking was not altered by s.c. administration of an oxytocin antagonist (1-deamino-2-d-Tyr-(Oet)-4-Thr-8-Orn-oxytocin, 1 mg/kg) directed against the uterine receptor. In contrast, the administration of 0.1 mg/kg of oxytocin diminished the effect, which was antagonized by a simultaneous injection of the oxytocin antagonist. These results indicate that the massage-like stroking of the abdomen decreases blood pressure in anesthetized rats. This effect does not involve intrinsic oxytocinergic transmission. However, since exogenously applied oxytocin was found to diminish the effect of stroking, oxytocin may exert an inhibitory modulatory effect on this reflex arc.

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      References

        • Ågren G.
        • Lundeberg T.
        • Uvnäs-Moberg K.
        • Sato A.
        The oxytocin antagonist 1-deamino-2-d-Tyr-(Oet)-4-Thr-8-Orn-oxytocin reverses the increases in the withdrawal response latency to thermal, but not mechanical nociceptive stimuli following oxytocin administration or massage-like stroking in rats.
        Neurosci. Lett. 1995; (in press)
        • Araki T.
        • Ito K.
        • Kurosawa M.
        • Sato A.
        Responses of adrenal sympathetic nerve activity and catecholamine secretion to cutaneous stimulation in anesthetized rats.
        Neuroscience. 1984; 12: 289-299
        • Callahan M.F.
        • Kirby R.F.
        • Cunningham J.T.
        • Eskridge-Sloop S.L.
        • Johnson A.K.
        • McCarty R.
        • Gruber K.A.
        Central oxytocin systems may mediate a cardiovascular response to acute stress in rats.
        Am. J. Physiol. 1989; 256: H1369-H1377
        • Gibbs D.M.
        Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress.
        Life Sci. 1984; 35: 487-491
        • Gibbs D.M.
        Inhibition of corticotropin release during hypothermia: the role of corticotropin-releasing factor, vasopressin, and oxytocin.
        Endocrinology. 1985; 116: 723-727
        • Gibbs D.M.
        Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review.
        Psychoneuroendocrinology. 1986; 11: 131-140
        • Kametani H.
        • Sato A.
        • Sato Y.
        • Simpson A.
        Neural mechanisms of reflex facilitation and inhibition of gastric motility to stimulation of various skin areas in rats.
        J. Physiol. 1979; 294: 407-418
        • Kanetake C.
        A method for continuous drawing of blood from the jugular vein and drug injection in mice and rats.
        Jpn. J. Bacteriol. 1982; 37 (in Japanese): 943-947
        • Kaufman A.
        • Sato A.
        • Sato Y.
        • Sugimoto H.
        Reflex changes in heart rate after mechanical and thermal stimulation of the skin at various segmental levels in cats.
        Neuroscience. 1977; 2: 103-109
        • Koizumi K.
        • Sato A.
        • Terui N.
        Role of somatic afferents in autonomic system control of the intestinal motility.
        Brain Res. 1980; 182: 85-97
        • Kurosawa M.
        • Saito H.
        • Sato A.
        • Tsuchiya T.
        Reflex changes in sympatho-adrenal medullary functions in response to various thermal cutaneous stimulations in anesthetized rats.
        Neurosci. Lett. 1985; 56: 149-154
        • Kurosawa M.
        • Suzuki A.
        • Utsugi K.
        • Araki T.
        Response of adrenal efferent nerve activity to non-noxious mechanical stimulation of the skin in rats.
        Neurosci. Lett. 1982; 34: 295-300
        • Lundeberg T.
        • Uvnäs-Moberg K.
        • Ågren G.
        • Bruzelius G.
        Anti-nociceptive effects of oxytocin in rats and mice.
        Neurosci. Lett. 1994; 170: 153-157
        • Plotsky P.M.
        • Bruhn T.O.
        • Vale W.
        Evidence for multifactorial regulation of the adrenocorticotropin response to hemodynamic stimuli.
        Endocrinology. 1985; 116: 633-639
        • Sato A.
        • Sato Y.
        • Schmidt R.F.
        Heart rate changes reflecting modifications of efferent cardiac sympatheticoutflow by cutaneous and muscle afferent volleys.
        J. Auton. Nerv. Syst. 1981; 4: 231-247
        • Sato A.
        • Sato Y.
        • Shimada F.
        • Torigata Y.
        Changes in vesical function produced by cutaneous stimulation in rats.
        Brain Res. 1975; 94: 465-474
        • Sato A.
        • Sato Y.
        • Sugimoto H.
        • Terui N.
        Reflex changes in the urinary bladder after mechanical and thermal stimulation of the skin at various segmental levels in cats.
        Neuroscience. 1977; 2: 111-117
        • Stock S.
        • Uvnäs-Moberg K.
        Increased plasma levels of oxytocin in response to afferent electrical stimulation of the sciatic and vagal nerves and in response to touch and pinch in anesthesized rats.
        Acta Physiol. Scand. 1988; 132: 29-34