Abstract
Interstitial cells of Cajal (ICC) in the guinea pig intestine, identified by the tyrosine
kinase receptor, c-Kit, have been shown with immunohistochemistry to express nucleotide
P2X2 and P2X5 receptors. P2X5 receptors have also been demonstrated on interstitial cells in the mouse ileum. It
is speculated that release of ATP from enteric nerves, enteric glial cells or from
contracting smooth muscle may provide a feedback mechanism for pacemaker activity
in the intestine.
Keywords
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Article info
Publication history
Accepted:
December 20,
2001
Received in revised form:
December 17,
2001
Received:
November 30,
2001
Identification
Copyright
© 2002 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
