Research Article| Volume 97, ISSUE 1, P55-58, April 18, 2002

Hypersensitivity to noradrenaline in human omental vein but not artery isolated from a patient with idiopathic orthostatic hypotension


      We investigated the smooth muscle contraction in response to noradrenaline (NA), endothelin-1 (ET) and 5-hydroxytryptamine (5-HT) in the omental artery and vein segments from a 67-year-old woman with idiopathic orthostatic hypotension. The blood vessels were obtained during the abdominal surgery and investigated in vitro. Noradrenaline, endothelin-1 and 5-hydroxytryptamine all induced a contraction in the artery and vein segments. Compared to the literature, the sensitivity to noradrenaline was 10 times higher than expected in the vein. In the artery, the sensitivity to noradrenaline and in both the artery and vein, the sensitivity to endothelin-1 and 5-hydroxytryptamine was similar to that reported in the literature. These results suggest that the patient had developed an isolated hypersensitivity to noradrenaline in the veins, probably due to an impairment of the sympathetic activity.


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        • Adner M.
        • Cantera L.
        • Ehlert F.
        • Nilsson L.
        • Edvinsson L.
        Plasticity of contractile endothelin-B receptors in human arteries after organ culture.
        Br. J. Pharmacol. 1996; 119: 1159-1166
        • Ambrosi P.
        • Alonzo B.
        • Jaquet P.
        • Lemacon T.
        • Luccioni R.
        Neurosarcoidose avec dysautonomie.
        Presse Med. 1995; 24: 958
        • Cannavo S.
        • Romano C.
        • Buffa R.
        • Faglia G.
        Granulomatous sarcoidotic lesion of hypothalamic–pituitary region associated with Rathke's cleft cyst.
        J. Endocrinol. Invest. 1997; 20: 77-81
        • Frank H.J.
        • Frewin D.B.
        • Robinson S.M.
        • Wise P.H.
        Cardiovascular responses in diabetic dysautonomia.
        Aust. N. Z. J. Med. 1972; 2: 1-7
        • Grubb B.P.
        • Samoil D.
        • Kosinski D.
        • Wolfe D.
        • Lorton M.
        • Madu E.
        Fluoxetine hydrochloride for the treatment of severe refractory orthostatic hypotension.
        Am. J. Med. 1994; 97: 366-368
        • Kafka M.S.
        • Polinsky R.J.
        • Williams A.
        • Kopin I.J.
        • Lake C.R.
        • Ebert M.H.
        • Tokola N.S.
        Alpha-adrenergic receptors in orthostatic hypotension syndromes.
        Neurology. 1984; 34: 1121-1125
        • Kaufmann H.
        • Oribe E.
        • Oliver J.A.
        Plasma endothelin during upright tilt: relevance for orthostatic hypotension?.
        Lancet. 1991; 338: 1542-1545
        • Kontos H.A.
        • Richardson D.W.
        • Norvell J.E.
        Norepinephrine depletion in idiopathic orthostatic hypotension.
        Ann. Intern. Med. 1975; 82: 336-341
        • Lehmann M.
        • Gastmann U.
        • Tauber R.
        • Weiler C.
        • Pilot R.
        • Hirsch F.H.
        • Auch-Schwelk W.
        • Keul J.
        Katecholaminverhalten, Adrenorezeptorendichte an intakten Zellen und Katecholaminempfindlichkeit bei einer Patientin mit orthostatischer Hypotonie.
        Klin. Wochenschr. 1986; 64: 1249-1254
        • Lehmann M.
        • Hirsch F.W.
        • Auch-Schwelk W.
        • Alnor J.
        • Ochs A.
        • Gastmann U.
        • Keul J.
        Primäre orthostatische Hypotonie.
        Ein Fallbericht. Z. Kardiol. 1986; 75: 117-121
        • Polinsky R.J.
        • Kopin I.J.
        • Ebert M.H.
        • Weise V.
        Pharmacologic distinction of different orthostatic hypotension syndromes.
        Neurology. 1981; 31: 1-7
        • Riezebos J.
        • Watts I.S.
        • Vallance P.J.
        Endothelin receptors mediating functional responses in human small arteries and veins.
        Br. J. Pharmacol. 1994; 111: 609-615
        • Samoil D.
        • Grubb B.P.
        Neurally mediated syncope and serotonin reuptake inhibitors.
        Clin. Auton. Res. 1995; 5: 251-255
        • Steen S.
        • Skärby T.V.
        • Norgren L.
        • Andersson K.E.
        Pharmacological characterization of postjunctional alpha-adrenoceptors in isolated human omental arteries and veins.
        Acta Physiol. Scand. 1984; 120: 109-116
        • Törnebrandt K.
        • Nobin A.
        • Owman Ch.
        Serotonergic smooth muscle receptors in human mesenteric arteries and veins.
        in: Nobin A. Owman Ch. Arneklo-Nobin B. Neuronal Messengers in Vascular Function. Elsevier, Amsterdam1987: 31-44
        • Verbeuren T.J.
        • Jordaens F.H.
        • Herman A.G.
        Accumulation and release of [3H]-5-hydroxytryptamine in saphenous veins and cerebral arteries of the dog.
        J. Pharmacol. Exp. Ther. 1983; 226: 579-588
        • Wallerstedt S.M.
        • Bodelsson M.
        Endothelium-dependent relaxation by substance P in human isolated omental arteries and veins: relative contribution of prostanoids, nitric oxide and hyperpolarization.
        Br. J. Pharmacol. 1997; 120: 25-30
        • Wallerstedt S.M.
        • Törnebrandt K.
        • Bodelsson M.
        Characteristics of contractile 5-HT receptors in isolated human omental arteries: presence of 5-HT1 and 5-HT2 receptors.
        Pharmacol. Toxicol. 1996; 78: 50-54
        • Werbel S.S.
        • Ober K.P.
        Acute adrenal insufficiency.
        Endocrinol. Metab. Clin. North Am. 1993; 22: 303-328
        • White M.
        • Cernacek P.
        • Courtemanche M.
        • Stewart D.
        • Talajic M.
        • Mikes E.
        • Vantrimpont P.
        • Bussieres L.
        • Rouleau J.L.
        Impaired endothelin-1 release in tilt-induced syncope.
        Am. J. Cardiol. 1998; 81: 460-464
        • Ziegler M.G.
        • Lake C.R.
        • Kopin I.J.
        The sympathetic-nervous-system defect in primary orthostatic hypotension.
        N. Engl. J. Med. 1977; 296: 293-297