Abstract
Previously, we observed that in mice, olfactory stimulation with scent of grapefruit
oil elevates renal sympathetic nerve activity and blood pressure. In contrast, olfactory
stimulation with scent of lavender oil has opposite effects in mice. Moreover, electrolytic
lesions of the mouse hypothalamic suprachiasmatic nucleus eliminated changes in renal
sympathetic nerve activity and blood pressure induced by either scent of grapefruit
oil or scent of lavender oil. Here, we show that grapefruit oil-induced elevations
in renal sympathetic nerve activity and blood pressure were not observed in Clock mutant mice, which harbor mutations in Clock and lack normal circadian rhythms, whereas lavender oil-suppressions were preserved
in Clock mutant mice. In addition, responses of c-Fos inductions in the suprachiasmatic nucleus
and paraventricular nucleus of the hypothalamus to scent of grapefruit oil observed
in wild-type mice were not observed in Clock mutant mice. These findings suggest that the Clock gene might be implicated in elevating responses of autonomic and cardiovascular functions
to olfactory stimulation with scent of grapefruit oil.
Keywords
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Article info
Publication history
Accepted:
December 3,
2007
Received in revised form:
November 29,
2007
Received:
October 3,
2007
Identification
Copyright
© 2007 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
