Abstract
The spleen is an important organ for tumor immunity, and the splenic sympathetic nerve
has a suppressive effect on splenic natural killer (NK) cytotoxicity. On the basis
of this and reports that Lentinus edodes (Shiitake mushroom) has tumor-inhibitory effects, the authors hypothesized that an
extract of a mycelial culture of L. edodes grown in a solid medium of sugar-cane bagasse and defatted rice bran–L·E·M–might affect the sympathetic splenic sympathetic nerve activity (Splenic-SNA)
and thus inhibit tumor proliferation. Thus, the effect of L·E·M on Splenic-SNA and
human cancer cell proliferation was examined. Splenic-SNA was found to be suppressed
by an intraduodenal L·E·M injection in urethane-anesthetized rats, which significantly
inhibited increases in the tumor volume of human colon and breast cancer cells implanted
in athymic nude mice. These findings suggest that L·E·M has an inhibitory effect on
tumor proliferation possibly via a reduction in NK cytotoxicity through the suppression
of Splenic-SNA.
Keywords
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Article info
Publication history
Accepted:
November 9,
2008
Received:
September 25,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
