The effect of massage on immune function and stress in women with breast cancer — A randomized controlled trial

  • A. Billhult
    Correspondence
    Correspondence author. FoU-enheten i Södra Älvsborg, Sven Eriksonsplatsen 4, S-503 38 Borås, Sweden. Tel.: +46 33 209863; fax: +46 33 209870.
    Affiliations
    Institute of Neuroscience and Physiology/Physiotherapy, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden

    Research and Development Unit in Primary Health Care, Södra Älvsborg County, Sweden
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  • C. Lindholm
    Affiliations
    Dept of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
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  • Ronny Gunnarsson
    Affiliations
    Research and Development Unit in Primary Health Care, Södra Älvsborg County, Sweden
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  • E. Stener-Victorin
    Affiliations
    Institute of Neuroscience and Physiology/Physiotherapy, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden

    Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
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      Abstract

      Objectives

      To examine the short-term effects of light pressure effleurage on circulating lymphocytes by studying the number and activity of peripheral blood natural killer (NK) cells in patients with breast cancer compared to a control group. Furthermore, the effect of light pressure effleurage on salivary cortisol levels, heart rate and blood pressure was studied.

      Design

      Single centre, prospective, randomized and controlled study.

      Methods

      Thirty women, aged 50 to 75 years (mean 61 sd=7.2) with breast cancer undergoing radiation therapy in a hospital in southwestern Sweden were enrolled in the study. They were allocated to either receive massage in the form of a full-body light pressure effleurage treatment, or a control visit where they were given an equal amount of attention. Blood samples, saliva, notation of heart rate and blood pressure were collected before and after massage/control visit. Differences in change over time between groups were analyzed by Student's t-test.

      Results

      Light pressure effleurage massage decreased the deterioration of NK cell activity occurring during radiation therapy. Furthermore it lowered heart rate and systolic blood pressure. No effects were demonstrated on cortisol and diastolic pressure.

      Conclusions

      A single full-body light pressure effleurage massage has a short-term effect on NK cell activity, systolic blood pressure and heart rate in patients with breast cancer. However, the long-term clinical importance of these findings needs to be further investigated.

      Keywords

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