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Visceral organ cross-sensitization — An integrated perspective

  • P.R. Brumovsky
    Correspondence
    Corresponding authors. Gebhart is to be contacted at Pittsburgh Center for Pain Research, W1444BST, 200 Lothrop Street, Pittsburgh, PA 15213, United States. Tel.: +1 412 383 5911; fax: +1 412 383 5466. Brumovsky, Pittsburgh Center for Pain Research, W1402BST, 200 Lothrop Street, Pittsburgh, PA 15213, United States, or School of Biomedical Sciences, Austral University, Buenos Aires, Argentina, Av. Pte. Perón 1500, B1629AHJ Pilar, Buenos Aires, Argentina.
    Affiliations
    Pittsburgh Center for Pain Research, Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

    School of Biomedical Sciences, Austral University, Buenos Aires, Argentina
    Search for articles by this author
  • G.F. Gebhart
    Correspondence
    Corresponding authors. Gebhart is to be contacted at Pittsburgh Center for Pain Research, W1444BST, 200 Lothrop Street, Pittsburgh, PA 15213, United States. Tel.: +1 412 383 5911; fax: +1 412 383 5466. Brumovsky, Pittsburgh Center for Pain Research, W1402BST, 200 Lothrop Street, Pittsburgh, PA 15213, United States, or School of Biomedical Sciences, Austral University, Buenos Aires, Argentina, Av. Pte. Perón 1500, B1629AHJ Pilar, Buenos Aires, Argentina.
    Affiliations
    Pittsburgh Center for Pain Research, Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
    Search for articles by this author

      Abstract

      Viscero-somatic referral and sensitization has been well documented clinically and widely investigated, whereas viscero-visceral referral and sensitization (termed cross-organ sensitization) has only recently received attention as important to visceral disease states. Because second order neurons in the CNS have been extensively shown to receive convergent input from different visceral organs, it has been assumed that cross-organ sensitization arises by the same convergence-projection mechanism as advanced for viscero-somatic referral and sensitization. However, increasing evidence also suggests participation of peripheral mechanisms to explain referral and sensitization. We briefly summarize behavioral, morphological and physiological support of and focus on potential mechanisms underlying cross-organ sensitization.

      Keywords

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