Abstract
Baroreflex sensitivity is recognized for its prognostic relevance to cardio-vascular
and cerebro-vascular risks. However, little is known about the long-term outcome of
baroreflex function in patients with carotid stenosis undergoing carotid stenting.
Heart rate variability and cardio-vascular autonomic function, including baroreflex
sensitivity, were examined using non-invasive methods in 22 adult patients who underwent
carotid stenting. They were compared with the normal control group with 22 sex- and
age-matched normal volunteers and the risk control group with 10 adult patients with
severe stenosis or even total occlusion of the carotid artery without stenting. The
groups of patients with stenting and risk controls had significantly reduced valsalva
ratio and baroreflex sensitivity measured by the valsalva method compared to normal
controls. However, there was no significant difference between patients with stenting
and risk controls. There was significant decrease in heart rate response to deep breathing
and to head-up tilt in patients with carotid stenting compared to normal controls.
Other parameters of cardio-vascular autonomic function showed no difference among
the three groups. Reduced baroreceptor function in patients with carotid stenting
may be due to underlying diseases rather than the stenting itself. There was no short-term
parasympathetic hyperactivity after the stenting, suggesting that the effect is transient
rather than permanent.
Keywords
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Article info
Publication history
Accepted:
June 21,
2010
Received in revised form:
April 24,
2010
Received:
March 13,
2010
Identification
Copyright
© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
