Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats

  • Momoe Iwami
    Affiliations
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

    Gifu City Women's College, 7-1 Hitoichibakitamachi, Gifu 501-0192, Japan
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  • Fatma A. Mahmoud
    Affiliations
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
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  • Takahiko Shiina
    Affiliations
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
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  • Haruko Hirayama
    Affiliations
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
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  • Takeshi Shima
    Affiliations
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
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  • Jun Sugita
    Affiliations
    Graduate School of Environmental and Symbiotic Science, Prefectural University of Kumamoto, Japan
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  • Yasutake Shimizu
    Correspondence
    Corresponding author. Tel./fax: +81 58 293 2940.
    Affiliations
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
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Published:December 24, 2010DOI:https://doi.org/10.1016/j.autneu.2010.11.012

      Abstract

      Grains of paradise (GP) is a species of the ginger family, Zingiberaceae, extracts of which have a pungent, peppery taste due to an aromatic ketone, 6-paradol. The aim of this study was to explore the thermogenic effects of GP extracts and of 6-paradol. Efferent discharges from sympathetic nerves entering the interscapular brown adipose tissue were recorded. Intragastric injection of a GP extract or 6-paradol enhanced the efferent discharges of the sympathetic nerves in a dose-dependent manner. The enhanced nerve discharges were sustained for as long as 3 h. The rats did not become desensitized to the stimulatory effects these compounds on sympathetic nerve activity. The tissue temperature of brown adipose tissue showed significant increase in rats injected with 6-paradol. These results demonstrate that GP extracts and 6-paradol activate thermogenesis in brown adipose tissue, and may open up new avenues for the regulation of weight loss and weight maintenance.

      Keywords

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