Severe dysmenorrhea (menstrual pain), now considered a chronic pain condition, [1]
is often associated with endometriosis, a painful disorder considered to be “estrogen-dependent”
and defined by its signs: extrauteral endometrial growths [10]. Many women with endometriosis
also suffer from other, mainly pelvic pains and conditions. Little is known about
how the signs relate to the symptoms (pains), making the pains of ENDO notoriously
difficult to treat. If analgesics are ineffective (often the case), then hormonal
treatments are added or surgery is done to remove ectopic growths. Hormonal treatments
alleviate the pain, but produce intolerable side effects, and pains generally resume
when therapy stops. Furthermore, surgery is effective at best in only half of selected
patients. New treatment approaches are badly needed [10].
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© 2010 Published by Elsevier Inc.
