Baroreflex changes only stressed volume not the slope of the venous return surface in anesthetized dogs

      Background: Although the Guyton's concept of venous return (VR) revolutionized circulatory physiology, the pulmonary circulation was not explicitly incorporated in its original framework. Since the pulmonary circulation is the critical element in understanding left heart failure, we extended the Guyton's original concept and characterized the VR as a surface described by both right (PRA) and left atrial pressures (PLA) as VR=VRmax(GSPRA+GPPLA) (AJP 2004). The baroreflex system is known to powerfully modulate systemic and pulmonary vascular systems and thereby capable of changing the circulatory equilibrium. However how baroreflex impacts the VR surface remains unknown.
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