Epidemiological studies have described an increase in the use of anabolic–androgenic steroids (AAS). Moreover, perhaps more importantly, evidence demonstrates that use of AAS is associated with psychotropic drug use, such as cocaine. Use of AAS and cocaine has been associated with cardiovascular complications. However, mechanisms involved on cardiovascular diseases associated with the use of these drugs, mainly their combined use, are not totally understood. Therefore, in the present study we investigated the effect of cocaine and/or testosterone administration for 1 or 10 consecutive days on baroreflex activity in unanesthetized rats.
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© 2010 Published by Elsevier Inc.