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Baroreflex mechanisms regulating the occurrence of sympathetic action potentials in human muscle sympathetic nerve activity

      Based on the integrated sympathetic neurogram it is understood that baroreflex mechanisms regulate the occurrence of sympathetic bursts but not their strength. These data suggest differential control over burst occurrence versus their size. These bursts are composed of single action potentials firing in multi-unit patterns. Our recent studies indicate that action potentials of larger size tend to appear in larger integrated bursts. As burst size is not related to a baroreflex mechanism, this study tested the hypothesis that the baroreflex exerts a differential regulatory influence over larger versus smaller action potential clusters in the human muscle sympathetic neurogram. Recently, we developed a new spike detection technique that enables the identification and morphological classification of sympathetic action potentials contributing to sympathetic bursts. Using this tool, we studied the relationship between the diastolic blood pressure and the probability of smaller versus larger sympathetic action potential occurrence.
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