Humans and socialised animals are able to exert a degree of voluntary control over
micturition. Failure of this control mechanism may underlie some forms of urinary
urge incontinence. Afferent signals from the distended bladder activate a spino-midbrain–spinal
pathway that initiates co-ordinated activity in the detrusor and external urethral
sphincter (EUS) muscles to induce voiding [1]. At midbrain level, critical synaptic
relays are located in the caudal ventrolateral periaqueductal grey matter (cvlatPAG)
[2]. We have recently shown that electrical stimulation within the cvlatPAG modulates
transmission through the reflex pathway [3]. We have now investigated whether chemical
stimulation using an excitatory amino acid produces the same effect.
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© 2010 Published by Elsevier Inc.
