Humans and socialised animals are able to exert a degree of voluntary control over micturition. Failure of this control mechanism may underlie some forms of urinary urge incontinence. Afferent signals from the distended bladder activate a spino-midbrain–spinal pathway that initiates co-ordinated activity in the detrusor and external urethral sphincter (EUS) muscles to induce voiding . At midbrain level, critical synaptic relays are located in the caudal ventrolateral periaqueductal grey matter (cvlatPAG) . We have recently shown that electrical stimulation within the cvlatPAG modulates transmission through the reflex pathway . We have now investigated whether chemical stimulation using an excitatory amino acid produces the same effect.
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© 2010 Published by Elsevier Inc.