Pre-treatment with purinergic antagonists alters the functional response to methacholine in the inflamed rat urinary bladder

      Purinoceptors are widely expressed in most tissues, including the rat urinary bladder, and are well known to possess both pro- and anti-inflammatory functions. Muscarinic receptors are the main contractile receptors in the rat urinary bladder. In the current study, we investigated the impact of pre-treatment with purinergic antagonists on the cholinergic contractile function of the rat urinary bladder during inflammation.
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