Role of the urothelium in afferent sensitivity to potassium in the mouse bladder

      Potassium sensitivity testing (high K+) for diagnosis in patients with bladder disorders is controversial, although it is considered predictive of increased urothelial permeability. As such high K+, as it diffuses across a leaky urothelium, is considered to directly depolarise sensory nerve endings. However, we hypothesised that high K+ may act at the level of the urothelium to release mediators that modulate afferent sensitivity indirectly.
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