Background: As elderly population increases, mood disorders have more often been seen, with major
depressive disorder being one of the most prevalent diseases. Depression is associated
with neuroendocrine and autonomic dysfunction, expressed by the increase in sympathetic
activity and/or reduction in parasympathetic activity. Activation in specific areas
of the cerebral cortex may be associated with both sympathetic activation and symptoms
of depression. The cardiac vagal control is reduced in older depressed and it could
be considered a risk factor for mortality related to cardiovascular diseases. However,
the relationship between electroencephalographic (EEG) alpha asymmetry and vagal modulation
in elderly depressed subjects is unknown.
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© 2010 Published by Elsevier Inc.
