P.031| Volume 163, ISSUE 1-2, P52-53, September 01, 2011

Analysis and treatment of cardiac alterations in an animal model of anxio-depressive pathologies

      Background: Anxiodepressive symptoms were associated with a significantly higher risk of fatal cardiovascular events. This appear to be attributable largely to an increase in sudden cardiac death, predicted by high sympathetic activity and decrease in heart rate variability. However, the central mechanism involved in this pathological alteration remained unknown. The dorsal medial nucleus of the hypothalamus (DMH) is part of acute arousal responses in stress (defense) situation, and its stimulation induces an increase in sympathetic activity. Our aim was to study the possible role of the DMH in the sympathetic alterations in chronic stress.
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