Alpha2 but not alpha1 and beta adrenoceptors in the lateral septal area modulates cardiovascular responses evoked by restraint stress in rats

      Background/aims: The lateral septal area (LSA) is involved in cardiovascular responses connected with emotional behavior. Restraint stress (RS) causes hypertension and tachycardia, and these responses are significantly reduced by microinjection of cobalt chloride (inhibitor synaptic) in LSA. RS also causes increased expression of c-fos in ASL, suggesting that this structure is involved in the modulation of cardiovascular responses evoked by the RS. Microdialysis studies showed that the levels of noradrenaline (NA) are increased during RS in several limbic regions involved in behavioral and autonomic responses, including LSA. Then, the aim of our study was to investigate the involvement of the noradrenergic system of ASL on the cardiovascular responses caused by the RS.
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