Background/aims: The lateral septal area (LSA) is involved in cardiovascular responses connected with
emotional behavior. Restraint stress (RS) causes hypertension and tachycardia, and
these responses are significantly reduced by microinjection of cobalt chloride (inhibitor
synaptic) in LSA. RS also causes increased expression of c-fos in ASL, suggesting
that this structure is involved in the modulation of cardiovascular responses evoked
by the RS. Microdialysis studies showed that the levels of noradrenaline (NA) are
increased during RS in several limbic regions involved in behavioral and autonomic
responses, including LSA. Then, the aim of our study was to investigate the involvement
of the noradrenergic system of ASL on the cardiovascular responses caused by the RS.
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© 2010 Published by Elsevier Inc.
