Contribution of excitatory amino acid receptors in the dorsomedial hypothalamus and periaqueductal gray to the asymmetry and lateralization in the cardiovascular responses to stress in rats

      Background/aims: Dorsomedial hypothalamus (DMH) and lateral / dorsolateral periaqueductal gray (PAG) are anatomically and functionally connected. Both DMH and PAG depend on glutamatergic inputs to be activated. We recently reported that removal of GABAergic tone in unilateral DMH produces: asymmetry – right sided predominance in cardiac chronotropism; lateralization – greater increases in ipsilateral renal sympathetic activity. This study investigated the role of the excitatory amino acids (EAA) of the DMH and PAG in the functional interhemispheric difference reported previously.
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