Localisation and function of muscarinic receptors in murine tracheal neurons

      Background/aims: Muscarinic receptors (MR) located on parasympathetic neurons modulate intraganglionic transmission and act as autoregulatory receptors at cholinergic nerve terminals. In the airways, it is postulated that the M2R serves this inhibitory feedback function, but recent studies on other organs point to a prominent role of the M4R subtype. Here, we aimed to identify the MR subtype inventory of murine tracheal neurons and to unravel their role in cholinergic feedback in airway control.
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