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Semaphorin 3F expression pattern coincides with the sympathetic nerve degeneration induced by oestrogen in the rat uterus

      Uterine sympathetic axons undergo regulated neurodegeneration in response to physiological and experimental increases in the circulating levels of oestrogen. This plasticity has been shown to be initiated by the target uterine tissue and involves alterations in the synthesis of repulsive signals for sympathetic nerves. Recently, transcriptome analyses of the oestrogen-primed rat uterus allowed us to identify a 5-fold induction of semaphorin 3F (Sema3F). This glycoprotein is a member of the vertebrate class-3 secreted semaphorins and has been shown to be a sympathetic nerve repellent by binding to neuropilin-2, a receptor present on the surface of sympathetic axon terminals.
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