Abstract
Chronic autonomic function and sleep architecture changes in patients post-stroke
are not well understood. Using wireless polysomnographic recordings, this study aimed
to investigate the long-term effects on sleep patterns and autonomic function in free
moving rats after middle cerebral artery occlusion (MCAO). The sleep pattern and heart
rate variability (HRV) of Wistar-Kyoto rats (WKY) were analyzed. After 7–10 days, the rats were divided into two groups: an MCAO group (n=8) and a sham surgery group (n=8). Compared with shams, MCAO rats showed decreased accumulated quiet sleep (QS) time
over 24 h during the 3rd week. The time percentage, duration and delta power of QS were also
significantly decreased in the MCAO group during the dark period. Compared with baseline,
there were significant increases in the parasympathetic-associated HRV measures in
the sham group, including the total power (TP), high frequency power (HF) and lower
frequency power (LF), throughout the post-operative weeks (primarily the 2nd and 3rd
weeks), reflecting a developmental increase of parasympathetic modulation; the normalized
LF and the LF–HF ratio were unaffected. In great contrast, however, most of the HRV
measures in the MCAO group were not significantly changed. Therefore, this study showed
that the long-term effects of ischemic stroke injury involve retardation of the establishment
of parasympathetic enhancement and disturbance of the normal sleep–wake cycle.
Keywords
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Article info
Publication history
Published online: June 22, 2012
Accepted:
May 30,
2012
Received in revised form:
May 28,
2012
Received:
October 12,
2011
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
