Short communication| Volume 170, ISSUE 1-2, P66-69, September 25, 2012

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Bacillus anthracis lethal toxin induces complex changes in sympathetic nerve discharge regulation


      Bacillus anthracis lethal toxin (LeTx) alters blood pressure and visceral sympathetic nerve discharge (SND) regulation (Garcia et al., 2012). The present results indicate that LeTx infusions produce similar response profiles in peripheral (lumbar) and visceral (renal) SND; an initial widespread activation of sympathetic nerve outflow, followed by a generalized reduction in lumbar and renal SND from peak levels, although the sympathoinhibition tended to be attenuated in lumbar SND. Combined hypoxia+hypercapnia during the hypotensive phase of LeTx infusions increased lumbar and renal SND, indicating that sympathetic neural circuits can be activated during the circulatory shock phase of B. anthracis septicemia.


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        • Baron R.
        • Jänig W.
        • Kollman W.
        Sympathetic and afferent somata projecting in hindlimb nerves and the anatomical organization of the lumbar sympathetic nervous system of the rat.
        J. Comp. Neurol. 1998; 275: 460-468
        • Cui X.
        • Moayeri M.
        • Li Y.
        • Li X.
        • Haley M.
        • Fitz Y.
        • Correa-Araujo R.
        • Banks S.M.
        • Leppla S.H.
        • Eichacker P.Q.
        Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004; 286: R699-R709
        • Cui X.
        • Li Y.
        • Moayeri M.
        • Choi G.H.
        • Subramanian G.M.
        • Li X.
        • Haley M.
        • Fitz Y.
        • Feng J.
        • Banks S.M.
        • Leppla S.H.
        • Eichacker P.Q.
        Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis.
        J. Infect. Dis. 2005; 191: 422-434
        • Cui X.
        • Li Y.
        • Li X.
        • Haley M.
        • Moayeri M.
        • Fitz Y.
        • Leppla S.H.
        • Eichacker P.Q.
        Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival.
        J. Infect. Dis. 2006; 193: 829-840
        • Garcia A.A.
        • Fels R.J.
        • Mosher L.J.
        • Kenney M.J.
        Bacillus anthracis lethal toxin alters regulation of visceral sympathetic nerve discharge.
        J. Appl. Physiol. 2012; 112: 1033-1040
        • Hosking K.G.
        • Fels R.J.
        • Kenney M.J.
        Inhibition of RVLM synaptic activation at peak hyperthermia reduces visceral sympathetic nerve discharge.
        Auton. Neurosci. 2009; 150: 104-110
        • Kanbar R.
        • Chapuis B.
        • Oréa V.
        • Barrés C.
        • Julien C.
        Baroreceptor control of lumbar and renal sympathetic nerve activity in conscious rats.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008; 295: R8-R14
        • Kenney M.J.
        Frequency characteristics of sympathetic nerve discharge in anesthetized rats.
        Am. J. Physiol. 1994; 267: R830-R840
        • Kenney M.J.
        • Fels R.J.
        Sympathetic nerve regulation to heating is altered in senescent rats.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002; 283: R513-R520
        • Kenney M.J.
        • Claassen D.E.
        • Bishop M.R.
        • Fels R.J.
        Regulation of the sympathetic nerve discharge bursting pattern during heat stress.
        Am. J. Physiol. 1998; 275: R1992-R2001
        • Leepla S.H.
        Anthrax toxin.
        in: Aktories K.J. Bacterial Protein Toxins. Springer, New York2000: 445-472
        • Mock M.
        • Fouet A.
        Annu. Rev. Microbiol. 2001; 55: 647-671
        • Morrison S.F.
        Differential control of sympathetic outflow.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001; 281: R683-R698
        • Ramchandra R.
        • Barrett C.J.
        • Guild S.J.
        • Malpas S.C.
        Evidence of differential control of renal and lumbar sympathetic nerve activity in conscious rabbits.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006; 290: R701-R708
        • Shimokawa A.
        • Kunitake T.
        • Takasaki M.
        • Kannan H.
        Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats.
        J. Auton. Nerv. Syst. 1998; 72: 46-54
        • Wallin B.G.
        • Charkoudian N.
        Sympathetic neural control of integrated cardiovascular function: insights from measurement of human sympathetic nerve activity.
        Muscle Nerve. 2007; 36: 595-614