Abstract
The enteric nervous system (ENS) consists of several neuronal subclasses with distinct
functional properties. The formation and maintenance of these distinct populations
during development and aging is dependent on the support of appropriate neurotrophic
factors. During early postnatal development, the ENS has to adept continuously to
changing alimentation situations, which might also affect neuronal maturation and
differentiation. There is evidence that basic-fibroblast-growth-factor (Fgf2) exerts
neurotrophic effects in the ENS. In this study primary myenteric plexus cultures from
both wild type and Fgf2-knockout mice were investigated under the influence of Fgf2
and glial-cell-line-derived-factor (GDNF). It could be demonstrated, that the influence
of neurotrophic support is decreased in the Fgf2-knockouts, while the neuronal cultures
of wild type revealed a more pronounced receptiveness for trophic support. These data
show that Fgf2 plays a role in the development of the ENS.
Keywords
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Article info
Publication history
Published online: August 06, 2012
Accepted:
July 16,
2012
Received in revised form:
July 12,
2012
Received:
March 17,
2011
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
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- Corrigendum to “Enteric neurons from postnatal Fgf2 knockout mice differ in neurite outgrowth responses” [Auton Neurosci 170 (1–2) 56–61]Autonomic Neuroscience: Basic and ClinicalVol. 174Issues 1-2
