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Baroreflex control of renal sympathetic nerve activity in mice with cardiac hypertrophy

  • Agata L. Gava
    Correspondence
    Corresponding author at: Lab Transgenes and Cardiovascular Control, Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Av Marechal Campos 1468, 29042‐755 Vitoria, ES, Brazil. Tel.: +55 27 3335 7487; fax: +55 27 3335 7330.
    Affiliations
    Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil

    Biotechnology Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
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  • Camille M. Balarini
    Affiliations
    Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
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  • Veronica A. Peotta
    Affiliations
    Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
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  • Glaucia R. Abreu
    Affiliations
    Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
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  • Antonio M. Cabral
    Affiliations
    Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
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  • Elisardo C. Vasquez
    Affiliations
    Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil

    Research Center, Emescam College of Health Sciences, Vitoria, ES, Brazil
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  • Silvana S. Meyrelles
    Affiliations
    Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil

    Biotechnology Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
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      Abstract

      Altered renal sympathetic nerve activity (RSNA) plays a major role in the progression of cardiac hypertrophy. We aimed to evaluate the baroreflex control of RSNA in mice with cardiac hypertrophy. Swiss Webster mice were treated with isoproterenol (15 μg/g/day, s.c.) or vehicle and the baroreflex evaluation was performed by measuring changes in RSNA in response to changes in arterial pressure. The maximal gain of the reflex changes in RSNA was reduced in isoproterenol-treated animals (1.39±0.08%/mm Hg) in comparison with vehicle-treated animals (1.77±0.10%/mm Hg). Therefore, we can conclude that cardiac hypertrophy led to a reduced sensitivity of baroreflex control of RSNA.

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