Abstract
Altered renal sympathetic nerve activity (RSNA) plays a major role in the progression
of cardiac hypertrophy. We aimed to evaluate the baroreflex control of RSNA in mice
with cardiac hypertrophy. Swiss Webster mice were treated with isoproterenol (15 μg/g/day, s.c.) or vehicle and the baroreflex evaluation was performed by measuring
changes in RSNA in response to changes in arterial pressure. The maximal gain of the
reflex changes in RSNA was reduced in isoproterenol-treated animals (1.39±0.08%/mm Hg) in comparison with vehicle-treated animals (1.77±0.10%/mm Hg). Therefore, we can conclude that cardiac hypertrophy led to a reduced
sensitivity of baroreflex control of RSNA.
Keywords
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Article info
Publication history
Published online: August 27, 2012
Accepted:
August 7,
2012
Received in revised form:
July 16,
2012
Received:
June 18,
2012
Identification
Copyright
© 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
