Abstract
The dorsal motor nucleus of vagus (DMV) plays an important role in the regulation
of gastrointestinal function. Dopamine (DA) exerts potent neuromodulatory effects
on the motoneurons in the DMV via dopamine receptors (DRs). However, the distribution
of DRs and their neurochemical phenotypes in the DMV are unclear. In the present study,
the distribution of DRs D1- and D2-immunoreactive (IR) neurons and their neurochemical phenotypes in the DMV of rats
were investigated using a double-labeling immunofluorescence technique combined with
confocal microscopy. The results indicated that a considerable quantity of D1 and D2 was expressed throughout the DMV. A large amount of choline acetyltransferase (ChAT)-IR
and a few tyrosine hydroxylase (TH)-IR neurons were observed in the DMV. Nearly all
of the neurons were also D1-IR and D2-IR. In conclusion, the present study demonstrates the wide distribution of D1 and D2 in the cholinergic and catecholaminergic neurons in the DMV of rats. The DRs might
play an important role in the regulation of DA on the activity of cholinergic and
catecholaminergic neurons in the DMV.
Keywords
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Article info
Publication history
Published online: February 11, 2013
Accepted:
January 13,
2013
Received in revised form:
January 10,
2013
Received:
December 19,
2012
Identification
Copyright
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
