The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Here we review three papers to highlight the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological regulator of a hypothermic state in both hibernating and non-hibernating mammals. We would like to emphasize the importance of comparative studies between hibernating and non-hibernating species that could lead to important discoveries on the mechanisms inducing hibernation and how they might be translated to induce a clinically useful hypothermic state.
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- A source of adenosine involved in cardiovascular responses to defense area stimulation.Am. J. Physiol. 1997; 272: R195-R200
Published online: March 04, 2013
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.