Abstract
The positive outcome that hypothermia contributes to brain and cardiac protection
following ischemia has stimulated research in the development of pharmacological approaches
to induce a hypothermic/hypometabolic state. Here we review three papers to highlight
the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological
regulator of a hypothermic state in both hibernating and non-hibernating mammals.
We would like to emphasize the importance of comparative studies between hibernating
and non-hibernating species that could lead to important discoveries on the mechanisms
inducing hibernation and how they might be translated to induce a clinically useful
hypothermic state.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Autonomic Neuroscience: Basic and ClinicalAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
Reference
- A source of adenosine involved in cardiovascular responses to defense area stimulation.Am. J. Physiol. 1997; 272: R195-R200
Article info
Publication history
Published online: March 04, 2013
Identification
Copyright
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
