Research Article| Volume 176, ISSUE 1-2, P1-2, June 2013

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Highlights in basic autonomic neurosciences: Central adenosine A1 receptor — The key to a hypometabolic state and therapeutic hypothermia?


      The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Here we review three papers to highlight the role of the adenosine 1 receptor (A1AR) as a potential mediator and physiological regulator of a hypothermic state in both hibernating and non-hibernating mammals. We would like to emphasize the importance of comparative studies between hibernating and non-hibernating species that could lead to important discoveries on the mechanisms inducing hibernation and how they might be translated to induce a clinically useful hypothermic state.


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        • St Lambert J.H.
        • Thomas T.
        • Burnstock G.
        • Spyer K.M.
        A source of adenosine involved in cardiovascular responses to defense area stimulation.
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