Advertisement
Abstract| Volume 177, ISSUE 1, P23, August 2013

Astroglial control of presympathetic circuits

      Heart failure leads to hypoperfusion and hypooxygenation of tissues and this is often exacerbated by sleep apnoeas associated with recurrent episodes of systemic hypoxia and hypercapnia/hypocapnia. Astrocytes residing in the rostral ventrolateral medulla oblongata (RVLM) may function as brain chemoreceptors. They sense PCO2/pH changes and via release of ATP impart these changes on the respiratory neurones triggering adaptive increases in breathing. We used in vitro and in vivo models to determine whether selective activation of RVLM astrocytes is also capable of increasing the activity of sympathoexcitatory (pre-sympathetic) RVLM neurones. We also explored whether ATP actions in the RVLM contribute to maladaptive and detrimental sympathoexcitation in heart failure.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Autonomic Neuroscience: Basic and Clinical
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect