Various types of mutations of the Paired-like Homeobox 2b (PHOX2B) and the Anaplastic Lymphoma Kinase (ALK) genes have been identified in neuroblastoma patients. Elucidating how each of these mutations affect the development of the sympatho-adrenal system broadens our understanding on the pathogenetic mechanisms of neuroblastoma. In this study, we focused on frameshift mutations of the PHOX2B gene identified in syndromic autonomic neurocristopathy patients and on the missense mutation of the ALK gene (F1174L), and introduced these mutations into the corresponding gene loci of the mouse through gene targeting.
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Received: May 15, 2013
© 2013 Published by Elsevier Inc.