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Cutaneous α-synuclein and Parkinson Disease, a biomarker of disease severity

      Background: Parkinson disease is a multisystem neurodegenerative disease with deposition of α-synuclein in the central, peripheral and enteric nervous systems. The most prominent manifestations of Parkinson disease are due to central, motor system neurodegeneration but there is also widespread peripheral, autonomic and enteric nervous system degeneration with associated clinical features.
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