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Hypoxia-induced augmented cardiorespiratory responses

      Brainstem networks interact in the control and coordination of cardiovascular and respiratory functions. This interaction, referred to as cardiorespiratory coupling, is evident in common rhythms in autonomic and respiratory motor activities. It is well recognized that respiration modulates vagal and sympathetic nerve (SNA) activities; not so well recognized is the reciprocal interaction that arterial pulse pressure modulates respiratory motoneuronal activity. Further, sensory feedback that evokes a respiratory response also alters autonomic activities. Therefore, we hypothesize that the plasticity that is expressed in the respiratory control system is also expressed in SNA.
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