Abstract| Volume 177, ISSUE 1, P33-34, August 2013

Neuroepithelial bodies as airway hypoxia sensors: Re-evaluation of the concept in a GAD67-GFP mouse lung slice model

      Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of neuroendocrine cells, shielded from the airway lumen by Clara-like cells. For many years now, NEBs have been thought to sense changes in the composition of inhaled air. Acute hypoxia has been suggested to close oxygen-sensitive background K+ channels in NEB cells, resulting in membrane depolarization, voltage-gated Ca2+ entry and subsequent transmitter release.
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