Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of neuroendocrine
cells, shielded from the airway lumen by Clara-like cells. For many years now, NEBs
have been thought to sense changes in the composition of inhaled air. Acute hypoxia
has been suggested to close oxygen-sensitive background K+ channels in NEB cells, resulting in membrane depolarization, voltage-gated Ca2+ entry and subsequent transmitter release.
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Article info
Publication history
Received:
May 15,
2013
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Copyright
© 2013 Published by Elsevier Inc.