Abstract| Volume 177, ISSUE 1, P39, August 2013

Streptozotocin-induced diabetes reduces the density of sympathetic innervation and increases adrenosensitivity of small renal arteries in rats

      Autonomic neuropathy is a common complication of diabetes mellitus, but impairment of sympathetic innervation appears differently in different vascular beds. According our data, intermediate-stage (6-week) diabetes reduces the density of periarterial nerve plexus in small renal arteries by 30%. The aim of this study was to test the hypothesis that such partial denervation affects adrenosensitivity of renal arteries from diabetic rats and to explore the possible mechanisms.
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