Nanocarriers can often achieve superior therapeutic outcomes for drug delivery when
compared with standard drug formulations. However, concerns over their adverse effects
are growing due to the correlation between exposure to nanosized particles and cardiovascular
diseases. Here we examine the impact of intravenously injected drug-free nanocarriers
on the cardiovasculature at both systemic and organ levels. We combine in vivo and in vitro methods to enable monitoring of hemodynamic parameters in conscious rats, assessments
of the function of the vessels after sub-chronic systemic exposure to nanocarriers
and evaluation of the direct effect of nanocarriers on vascular tone.
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Article info
Publication history
Received:
May 15,
2013
Identification
Copyright
© 2013 Published by Elsevier Inc.
