Neurotrophic factors can alter the functional properties of sensory C-fibers in allergic
asthma. Neurturin is a neurotrophic factor in the Glial Cell Line-Derived Neurotrophic
Factor (GDNF) family of ligands, binds to its receptor GFRα2 and signals via co-receptor
RET. Previously, we were able to demonstrate that some bronchopulmonary vagal C-fibers
co-express not only GFRα2 and RET but also transient receptor potential channel vanilloid
1 and ankyrin 1 (TRPV1 and TRPA1). These TRP-channels are activated by many environmental
irritants that induce allergic reactions like dyspnea, cough, hypersecretion and bronchoconstriction
in patients suffering from allergic asthma. Therefore it has been speculated that
the dysfunction of the TRPV1 and TRPA1 receptors contributes to an enhanced excitability
of sensory C-fibers.
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Article info
Publication history
Received:
May 15,
2013
Identification
Copyright
© 2013 Published by Elsevier Inc.
