Neurotrophic factors can alter the functional properties of sensory C-fibers in allergic asthma. Neurturin is a neurotrophic factor in the Glial Cell Line-Derived Neurotrophic Factor (GDNF) family of ligands, binds to its receptor GFRα2 and signals via co-receptor RET. Previously, we were able to demonstrate that some bronchopulmonary vagal C-fibers co-express not only GFRα2 and RET but also transient receptor potential channel vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1). These TRP-channels are activated by many environmental irritants that induce allergic reactions like dyspnea, cough, hypersecretion and bronchoconstriction in patients suffering from allergic asthma. Therefore it has been speculated that the dysfunction of the TRPV1 and TRPA1 receptors contributes to an enhanced excitability of sensory C-fibers.
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Received: May 15, 2013
© 2013 Published by Elsevier Inc.