Acetylcholine is not only a neurotransmitter, but was detected in a variety of non-neuronal
cells. For example, choline acetyltransferase (ChAT) was found within the colonic
epithelium of rat and man (Klapproth et al. 1997) which provides those cells the potential
to synthesize acetylcholine. In Ussing chamber experiments it has been shown that
acetylcholine is released on the basolateral side by luminal stimulation with proprionate,
a short-chain fatty acid. The functional consequence is the induction of a chloride
secretion (Yajima et al. 2011). However, it is unclear how acetylcholine is produced
and released from these cells.
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Article info
Publication history
Received:
May 15,
2013
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Copyright
© 2013 Published by Elsevier Inc.
