Acetylcholine is not only a neurotransmitter, but was detected in a variety of non-neuronal cells. For example, choline acetyltransferase (ChAT) was found within the colonic epithelium of rat and man (Klapproth et al. 1997) which provides those cells the potential to synthesize acetylcholine. In Ussing chamber experiments it has been shown that acetylcholine is released on the basolateral side by luminal stimulation with proprionate, a short-chain fatty acid. The functional consequence is the induction of a chloride secretion (Yajima et al. 2011). However, it is unclear how acetylcholine is produced and released from these cells.
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Received: May 15, 2013
© 2013 Published by Elsevier Inc.