It has been over 2 decades since Vracko first demonstrated axon sprouting in the ischemic
rat and human heart (Vracko et al. 1990 Lab Invest 63:490–501; 1991 Hum Pathol 22:
138–146), and nearly 10 years since Chen, Fishbein, and colleagues revealed its significance in generation
of arrhythmias (Zhou et al. 2004 Circ Res 95: 76–83). Subsequent studies have now
shed new light on the actual extent and diversity of post-ischemic cardiac neuroplasticity.
We now understand that neuroplastic changes are complex, involving both regional sympathetic
degeneration and sprouting; that it involves interactions with both inflammatory cells
and myocardial cells whose developmental state may be altered; and that plasticity
extends beyond the heart, also involving the stellate ganglion. This “Highlights in
Autonomic Neuroscience” discusses recent findings on post-ischemic autonomic cardiac
plasticity.
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Publication history
Published online: September 26, 2013
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© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
