If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password
If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password
PériTox Laboratory (UMR-I 01 Ineris), Health Research University Center-Faculty of Medicine, Jules Verne University of Picardy, Amiens, FranceNeonatal and Pediatric Intensive Care Unit, Amiens University Medical Center, Amiens, France
PériTox Laboratory (UMR-I 01 Ineris), Health Research University Center-Faculty of Medicine, Jules Verne University of Picardy, Amiens, FrancePediatric Gastroenterology Unit, Amiens University Medical Center, Amiens, France
Background: It has been suggested that disturbed activity of the autonomic nervous
system is one of the factors involved in gastroesophageal reflux (GER) in adults.
We sought to establish whether transient ANS dysfunction (as assessed by heart rate
variability) is associated with the occurrence of GER events in neonates during sleep
and wakefulness. Methods: Nineteen neonates with suspected GER underwent simultaneous,
synchronized 12-hour polysomnography and esophageal multichannel impedance-pH monitoring.
We compared changes in HRV parameters during three types of periods (control and prior
to and during reflux) with respect to the vigilance state. Results: The vigilance
state influenced the distribution of GER events (P < 0.001), with 53.4% observed during wakefulness, 37.6% observed during active sleep
and only 9% observed during quiet sleep. A significant increase in the sympathovagal
ratio (+32%, P = 0.013) was observed in the period immediately prior to reflux (due to a 15% reduction
in parasympathetic activity (P = 0.017)), relative to the control period. This phenomenon was observed during both
wakefulness and active sleep. Conclusion: Our results showed that GER events were
preceded by a vigilance-state-independent decrease in parasympathetic tone. This suggests
that a pre-reflux change in ANS activity is one of the factors contributing to the
mechanism of reflux GER in neonates.
To read this article in full you will need to make a payment