Background: Inflammation has a major role in atherosclerosis and C-reactive protein
(CRP) is elevated in patients with coronary artery disease (CAD) (1). Moreover, inflammation
is also implicated in autonomic nervous system control (2). However, whether elevated
levels of CRP and reduced heart rate variability (HRV) play a role in the severity
of CAD remains controversial. Aim: The aim of the study was to evaluate and compare
high sensitivity CRP levels and HRV indices according severity of CAD. Methods: Eighty
seven patients (mean age 54 ± 5.39 years) with CAD (angiographically evaluated) were allocated according number of diseased
vessels: one vessel (G1, n = 26); two vessels (G2, n = 28); three or more vessels (G3, n = 33). Heart rate was measured at rest using a Polar®S810i for 15 min. HRV was analyzed by spectral(3) and symbolic analysis(4). CRP was measured by
nephelometry method. Statistical analysis: One way ANOVA test, with level of significance = 5%. Results: High sensitivity CRP levels and HRV indices did not differ between groups.
Conclusion: The results show that high sensitivity CRP and cardiac autonomic modulation
are not related to severity of CAD. 1. Drakopoulou M, Toutouzas K, Stefanadi E, Tsiamis
E, Tousoulis D, Stefanadis C. Association of inflammatory markers with angiographic
severity and extent of coronary artery disease. Atherosclerosis. 2009;206(2):335-9.
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© 2015 Published by Elsevier Inc.