Introduction: Baroreflex maintains blood pressure (BP) when there is change in heart
rate (HR) and total peripheral resistance. Valsalva maneuver (VM) is widely used to
quantify cardiovagal baroreflex sensitivity (cBRS). It is an important marker of vagal
reflexes. Autonomic dysfunction has been reported in spinocerebellar ataxia (SCA)
patients, but comparison of cardiovagal baroreflex sensitivity from phase IV of Valsalva
maneuver remains poorly reported in between SCA1 and SCA2 patients. It is also known
that cBRS is an important marker of vagal reflexes. In this context we tried to examine
the status of vagal activity in SCA 1 and 2 using phase IV of Valsalva maneuver. Method:
The recordings of continuous HR and BP during VM were analyzed to determine cBRS in
genetically proven SCA1 (n = 8, age = 35.8 ± 6.2 yrs) and SCA2 (n = 8, age = 33.8 ± 9.4 yrs) patients. Result: cBRS in SCA1 were found to have significantly lower (p = 0.0086) as compared to SCA2. Conclusion: We report significantly lower cBRS in SCA1
than SCA2. This higher vagal autonomic dysfunction in SCA1 than SCA2 may be important
for management of these ataxias.
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© 2015 Published by Elsevier Inc.
