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Comparison of cardiovagal baroreflex sensitivity from phase IV of Valsalva maneuver in SCA 1 and SCA 2 patients

      Introduction: Baroreflex maintains blood pressure (BP) when there is change in heart rate (HR) and total peripheral resistance. Valsalva maneuver (VM) is widely used to quantify cardiovagal baroreflex sensitivity (cBRS). It is an important marker of vagal reflexes. Autonomic dysfunction has been reported in spinocerebellar ataxia (SCA) patients, but comparison of cardiovagal baroreflex sensitivity from phase IV of Valsalva maneuver remains poorly reported in between SCA1 and SCA2 patients. It is also known that cBRS is an important marker of vagal reflexes. In this context we tried to examine the status of vagal activity in SCA 1 and 2 using phase IV of Valsalva maneuver. Method: The recordings of continuous HR and BP during VM were analyzed to determine cBRS in genetically proven SCA1 (n = 8, age = 35.8 ± 6.2 yrs) and SCA2 (n = 8, age = 33.8 ± 9.4 yrs) patients. Result: cBRS in SCA1 were found to have significantly lower (p = 0.0086) as compared to SCA2. Conclusion: We report significantly lower cBRS in SCA1 than SCA2. This higher vagal autonomic dysfunction in SCA1 than SCA2 may be important for management of these ataxias.
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