Background: Aging promotes increased levels of circulating proinflammatory markers
and decrease in cardiac autonomic function that can be evaluated by high sensitivity
C-reactive protein (hsCRP) and heart rate variability (HRV), respectively. Studies
shown relation between the immune system and HRV, however, few studies are related
to the baroreflex sensitivity (BRS). Aim: To evaluate the relationship between cardiovascular
autonomic nervous system (BRS) and hsCRP in natural human aging in a wide range of
age and gender. Methods: One hundred and ten apparently healthy individuals (without
hsCRP values suggestive of acute inflammation, above 3.0 mg/L) were divided into 2 groups (men and women) and then, equally assigned into 5
groups (21-30; 31-40; 41-50; 51-60 and 61-70 years), 11 subjects in each group. The
electrocardiographic, respiratory and noninvasive finger arterial pressure signals
were recorded for 15 minutes, in rest supine (REST) and in orthostatic position (STAND), and sampled at
400Hz. Stable sequences of 256 points in REST and STAND were chosen. Cross-spectral
analysis was performed to compute coherence, phase and BRS in low (LF) frequency.
Blood was collected after a 12-hour fasting. The turbidimetry method was used for
hsCRP analysis. Results: Spearman correlation test showed a negative significant relationship
(p < 0.05) between hsCRP and phase (r = -0.576) and between hsCRP and BRS (r = -0.356) in LF in STAND in women, however, no correlation was found in men. Conclusion:
The relationship between proinflammatory marker and cardiovascular autonomic nervous
system showed a gender dependency therefore gender should be taken into account in
the analysis of the cardiovascular autonomic nervous system. Financial support: FAPESP:
2010/52070-4; CNPq: 311938/2013-2; CNPq: 140164/2015-4.
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© 2015 Published by Elsevier Inc.