The vagus nerve connects peripheral organs with the central nervous system. Vagal
afferent neurons, located in the nodose ganglia, have processes terminating within
the lamina propria of the gut. These neurons express numerous receptors that sense
hormones released from the gut epithelium, and provide information about the quantity
and type of nutrients throughout the gut to the brain. There is evidence from surgical
and chemical lesioning studies, that vagal signaling from the gut to the brain is
involved in short-term control of food intake. Two key questions remain unanswered
in the field:
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© 2015 Published by Elsevier Inc.
