5.2| Volume 192, P8, November 2015

Role of gut to brain signaling in the development of diet-induced obesity

      The vagus nerve connects peripheral organs with the central nervous system. Vagal afferent neurons, located in the nodose ganglia, have processes terminating within the lamina propria of the gut. These neurons express numerous receptors that sense hormones released from the gut epithelium, and provide information about the quantity and type of nutrients throughout the gut to the brain. There is evidence from surgical and chemical lesioning studies, that vagal signaling from the gut to the brain is involved in short-term control of food intake. Two key questions remain unanswered in the field:
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