Cholecystokinin (CCK) is a peptide secreted by the I-cells of the small intestine
and evokes a variety of responses e.g. reduction of meal size (MS) and prolongation
of the intermeal interval (IMI, time between two consecutive meals). We have shown
that the areas supplied by the celiac artery (CA, supplies stomach and upper duodenum)
and the cranial mesenteric artery (CMA supplies small and part of the large intestine)
contain site of actions controlling the previous feeding responses, MS and IMI length,
in free feeding, undisturbed Sprague Dawley rats maintained on normal rat chow. Here,
we determined activation of the enteric neurons and dorsal vagal complex (DVC) by
two forms of CCK, CCK-8, the most used commercial form and CCK-58, the only endocrine
form of the peptide infused in the CA, CMA and the femoral artery (FA, control) prior
to the onset of the dark cycle. Sixty minutes following the infusion all rats were
sacrificed and Fos-like immunoreactivity (Fos-LI) was quantified in the myenteric
and the submucosal plexuses of the duodenum and in the hindbrain areas that control
food intake e.g. the dorsal motor nucleus of the vagus (DVC), area postrema (AP) and
nucleus tractus solitarius (NTS). We found that CCK-58 infused in the CA and CMA but
not in the FA increased Fos-LI in the myenteric and the submucosal plexuses and the
DVC. In Conclusion, these results provide further evidence that the areas supplied
by the CA and CMA contains sites of action controlling MS and IMI length by CCK-58.
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© 2015 Published by Elsevier Inc.