Respiration and heart rate related variations have very often been described as nuisance
factors, confounding the hemodynamic response in the brain (BOLD signal). Recently,
it has been argued that physiological signals should not necessarily be treated as
artifacts. These signals might be meaningful for investigating brain networks for
physiological control. The default mode network (DMN) is a resting state network containing
the ventromedial prefrontal cortex and posterior cingulate cortex as core regions.
Both regions are known to be part of central autonomic regulation. The presentation
will firstly describe the different methodological approaches to relate individual
cardiac parameters and BOLD signal during resting state in healthy subjects with significantly
different heart rates. The involvement of both regions in cardiac autonomic regulation
will be shown. Furthermore, our main goal was to clarify neural mechanisms underlying
autonomic dysregulations in patients with Major Depression (MDD) by comparing two
patient groups in the resting state condition with respect to different antidepressant
medication. In this analysis, the methods derived from the study with healthy controls
are applied. We will show in patients with MDD how varying cardiac parameter impact
BOLD signal fluctuation in brain regions of the DMN.
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© 2015 Published by Elsevier Inc.
