If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password
If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password
The thermoregulation system is a federation of relatively independent thermoeffector
loops coordinated by the overlapping control variables (“body temperatures, Tb’s”).
Each thermoeffector response is driven by a unique combination of Tb’s. Some superficial
(of hairy skin) and deep (of hypothalamus) Tb’s are considered most important. Tb
signals from the skin are converted into electric signals by temperature-sensitive
transient receptor potential (TRP) channels, and possibly other “thermosensors.” This
symposium will review the roles of different TRP channels in thermoregulation. Skin
Tb signals that drive thermoeffectors responses for defense against cold, at least
most of these responses and at least in rodents, are generated by TRPM8 (and possibly
other channels), but not TRPA1. We did not quantify contributions of skin Tb’s vs.
brain Tb’s to cold defenses, but our experiments show clearly that skin signals are
physiologically important. Skin Tb signals that drive warmth-defense thermoeffector
responses in rodents are generated by TRPV3 and TRPV4 (and possibly other channels),
but not TRPV1. However, our experiments show that the role of skin Tb’s in driving
these responses is usually unimportant. Skin TRPV1 does not seem to be involved in
converting skin Tb signals into electric signals driving thermoeffectors. However,
visceral TRPV1 channels are tonically activated by protons, and these low-pH signals
suppress at least some cold-defense responses in several mammal species, including
humans and rodents.
To read this article in full you will need to make a payment