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Transient receptor potential vanilloid-1 (TRPV1) is the founding member of larger
family of TRP ion channels. As a molecular integrator of multiple physical and chemical
stimuli, TRPV1 plays important role in numerous biological processes including thermoregulation.
In fact, involvement of TRPV1 in thermoregulation and thermosensation is so prominent
that it is hindering a development of safe drugs targeting other functions of TRPV1
such as emergence and the maintenance of pain. This presentation will review our current
understanding of thermoregulatory function of TRPV1 based on mechanistic studies conducted
by using pharmacological and genetic tools.
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